DNP- : (2,4-Dinitrophenol)
DNP- : (2,4-Dinitrophenol)
Substance: (2,4-Dinitrophenol)
Trade Names:
The substance; 2, 4-Dinitrophenol has many other brand names such as, 1 Hydroxy-2,4-dinitrophenol,
Solfo Black, Nitrophen, Aldifen, and Chemox are just a few and is among many things, a metabolic
stimulant. That is it's popularity here in our world, it burns fat like no other. Let me just tell you of it's
other uses before I continue. First, it is a toxic dye, chemically related to Trinitrophenol (Picric Acid),
second, it is found in insecticides, wood preservatives, herbicides, explosives, and is also a hazardous
material. Third, it is used in science to couple or attach to DNA molecules. All of this should tell you that
it is not a run-of-the-mill metabolic stimulant, like Clenbuterol or Triacana or Ephedrine or any other for
that matter. Here is DNP's tox faq's from the international chemical safety cards to you give an idea of
what it is considered to be; Combustible. Gives off irritating or toxic fumes (or gases) in a fire. Risk of
fire and explosion. DO NOT expose to friction or shock. MAY BE ABSORBED! Redness. Roughness.
Yellow staining on the skin. PHYSICAL STATE; APPEARANCE: YELLOW CRYSTALS ROUTES OF
EXPOSURE: The substance can be absorbed into the body by inhalation, through the skin and by
ingestion. PHYSICAL DANGERS: Dust explosion possible if in powder or granular form, mixed with air.
INHALATION RISK: Evaporation at 20C is negligible; a harmful concentration of airborne particles can,
however, be reached quickly. CHEMICAL DANGERS: May explosively decompose on shock, friction,
or concussion. May explode on heating. Shock-sensitive compounds are formed with alkalis, ammonia
and most metals. The substance decomposes on heating producing toxic gases including nitrogen
oxides. EFFECT OF SHORT-TERM EXPOSURE: The substance may cause effects on metabolism,
resulting in very high body temperature. Exposure may result in death. EFFECTS OF LONG TERM OR
REPEATED EXPOSURE: Repeated or prolonged contact with skin may cause dermatitis. The
substance may have effects on the peripheral nervous system. The substance may have effects on the
eyes, resulting in cataracts. Boiling point: sublimes C, Melting point: 112C, Relative density (water = 1):
1.68. Solubility in water, g/100 ml at 54.5C: 0.14. Relative vapor density (air = 1): 6.36. This product is
handled and shipped in a 15% solution of water, making it a paste, so that it will not explode due to
shock or friction.
DNP is an uncoupling agent that inhibits the flow of electrons and the pumping of H+ ions for ATP
synthesis. Fifty years ago it was used for weight loss, however, in 1938 the FDA removed it from the
counter, as it caused cataracts and even sometimes death. If electron transport does not produce ATP,
then much more sugar must be metabolized for energy needs. Very low production of ATP would be
lethal. In oxidative phosphorylation, the flow of electrons from NADH (the reduced form of NAD+,
oxidized from NAD. This enzyme is important in accepting electrons in the course of metabolic
reactions. When NAD+ gives up it's electron, it is converted to it's reduced form NADH) and FADH2
(the reduced form of FAD) to oxygen results in the pumping of H+ from the matrix to the inner
membrane space of the mitochondria. This gradient of H+ can produce ATP by flowing through ATP synthetase in the mitochondrial inner membrane. Dinitrophenol disrupts the H+ gradient reducing ATP
synthesis. Under these conditions, much of the food that we eat could not be used for ATP synthesis
and we lose weight. However, too much inhibitor and we could make too little ATP for life. The
difference between weight loss and death is only a small concentration change in dinitrophenol, making
the drug dangerous. Simply put, this means that while eating your normal diet, you will have
somewhere between 20% and 40% reduction of calories.
You may now be wondering just what kind of dose would be effective, but not harmful. A dose of
2mg/kg/day (or two mgs per kg of body weight per day) would be an effective dose, causing the loss of
about 5 to 10 pounds in a 10 to 14 day period, maybe less. So, a person weighing 200 lbs would weigh
about 91 kgs, so 2mgs per kg of body weight would be the equivalent of 182 mgs of DNP per day, but
since it typically comes in 200 mg capsules, you would take one cap per day. Since DNP has this
inhibiting effect, glycolosis is inhibited as well, causing a diabetic effect due to the conversion of glucose
without insulin, so you may have heard that people take insulin with DNP. This will counter act the
symptoms of lethargy and lack of energy due to DNP's use.
Finding DNP, this may be a little difficult as there are only two manufacturers of it. Sigma and
Springfield scientific, though they do not generally sell to the public, it is still available. If you cannot find
someone with capsules, you may try to get some bulk (somewhere around $20.00 - $30.00 per lb I
think), but since this is considered a hazardous material, it cannot be conveniently or inconspicuously
shipped (which for consumption is a felony), however, it is possible. However, to get use of the bulk/raw
form, you will need to make your own capsules, which is a meticulous process.
Ordering process |
